Early on bioRxiv.org
XXX. She F, Anderson BW, Khana DB, Zhang S, Steinchen W, Chun Fung DK, Lucas LN, Lesser NG, Stevenson DM, Astmann TJ, Bange G, van Pijkeren JP, Amador-Noguez D, Wang JD (2024). Allosteric Regulation of Pyruvate Kinase Enables Efficient and Robust Gluconeogenesis by Preventing Metabolic Conflicts and Carbon Overflow. doi: https://doi.org/10.1101/2024.08.15.607825
XXX. Liu Y, Karmakar R, Steinchen W, Mukherjee S, Bange G, Schafer LV, Thanbichler M (2024). Membrane binding properties of the cytoskeletal protein bactofilin. bioRxiv 2024.06.14.599034
XXX. Boudrioua A, Joiner JD, Grin I, Kronenberger T, Korotkov VS, Steinchen W, Kohler A, Schminke S, Schulte JC, Pietsch M, Naini A, Kalverkamp S, Hotop SK, Coyle T, Piselli C, Coles M, Rox K, Marschal M, Bange G, Flieger A, Poso A, Brönstrup M, Hartmann MD, Wagner S (2024). Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity. doi: https://doi.org/10.1101/2024.04.29.591313
XXX. Ast J, Bäcker N, Martorana D, Renicke C, Stehlik T, Heimerl T, Taxis C, Bange G, Bölker M, Sandrock B, Schink KO, Freitag J (2023). Selective accumulation of matrix proteins inside of peroxisomal subdomains.
bioRxiv 2022.10.02.510529
2024
142. Burgy O, Mayr CH, Schenesse D, Papakonstantinou EF, Ballester B, Sengupta A, She Y, Hu Q, Melo-Narvaéz C, Jain E, Pestoni JC, Mozurak M, Estrada-Bernal A, Onwuka U, Coughlan C, Parimon T, Chen P, Heimerl T, Bange G, Schmeck BT, Lindner M, Hilgendorff A, Ruppert C, Günther A, Mann M, Önder Yildirim A, Eickelberg O, Jung AL, Schiller HB, Lehmann M, Burgstaller G, Königshoff M (2024). Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis. Journal of Clinical Investigation, in press
141. Dornes A, Schmidt LM, Mais NC, Hook J, Pane-Farre J, Kressler D, Thormann K, Bange G (2024). Polar confinement of a macromolecular machine by a SRP-type GTPase. Nature Communications, 15(1):5797
140. Jakob Sendker FL, Schlotthauer T, Mais CN, Lo YK, Girbig M, Bohn S, Heimerl T, Schindler D, Weinstein A, Metzger BP, Thornton JW, Pillai A, Bange G, Schuller JM, Hochberg GKA (2024). Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. Nature Communications. In press
139. Freitag J, Stehlik T, Zalckvar E, Bange G (2024). Mitochondria, Peroxisomes and beyond – how dual targeting regulates organelle tethering. Contact, in press
138. Bischoff A, Ortelt J, Dünschede B, Zegarra V, Bedrunka P, Bange G, Schünemann D (2024). The role of chloroplast SRP54 domains and its C-terminal tail region in post- and cotranslational protein transport in vivo. Journal of Experimental Botany, 11:erae293.
137. Burt M, Angelidou G, Mais CN, Preußer C, Glatter T, Heimerl T, Groß R, Serrania J, Boosarpu G, Pogge von Strandmann E, Müller JA, Bange G, Becker A, Lehmann M, Jonigk D, Neubert L, Freitag H, Paczia N, Schmeck B, Jung AL (2024). Lipid A in outer membrane vesicles shields bacteria from polymyxins. Journal of Extracellular Vesicles 13(5):e12447
136. Ross, Wenhao Xu, Ekaterina Jalomo-Khayrova, Bange G, Gumerov V, Bradley P, Sourjik V, Jouline I (2024). Framework for exploring sensory repertoire of the human gut microbiota. mBio, 17:e0103924.
135. Sendker FL, Lo YK, Heimerl T, Bohn S, Persson L, Mais CM, Sadowska W, Paczia N, Nußbaum E, del Carmen Sánchez Olmos M, Forchhammer K, Schindler D, Erb TJ, Benesch JLP, Marklund EG, Bange G, Schuller JM, Hochberg GKA (2024). Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature, 628(8009):894-900
134. Bittner E, Stehlik T, Lam J, Dimitrov L, Heimerl T, Schöck I, Harberding J, Dornes A, Heymons N, Bange G, Schuldiner M, Zalckvar E, Bölker M, Schekman R, Freitag J (2024). Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles. PLOS Biology, 22(2):e3002508
133. Dornes A, Mais CN, Bange G (2024). The structure of the GDP-bound state of the SRP-GTPase FlhF. Acta Crystallographica F, 80(3):53-58
132. Eilers K, Yam JKH, Liu X, Goh YF, To K, Paracuellos P, Morton R, Brizuela J, Yong AMH, Givskov M, Freibert SA, Bange G, Rice S, Steinchen W, Filloux A (2024). The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture. Journal of Biological Chemistry, 16:105659
131. Jakob S, Steinchen W, Hanssmann J, Rosum J, Langenfeld K, Osorio-Valeriano M, Steube N, Giammarinaro PI, Hochberg GKA, Glatter T, Bange G, Diepold A, Thanbichler M (2024). The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression. Nature Communications, 15(1):318
2023
130. Joiner JD, Steinchen W, Kronenberger T, Bange G, Wagner S, Poso A, Hartmann MD (2023). HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids.
Journal of Biological Chemistry, 299(12):105387
129. Kohm K, Jalomo-Khayrova E, Krüger A, Basu S, Steinchen W, Bange G, Fruntzke J, Hertel R, Commichau FM, Czech L (2023). Structural and functional analysis of YopR, the master repressor of the Bacillus subtilis prophage SPb.
Nucleic Acids Research, 21:gkad675. doi: 10.1093/nar/gkad675
128. Brückner S, Müller F, Schadowski L, Kalle T, Weber S, Marino E, Kutscher B, Möller AM, Adler S, Begerow D, Steinchen W, Bange G, Narberhaus F (2023). (p)ppGpp and moonlighting RNases influence the first step of lipopolysaccharide biosynthesis in Escherichia coli. microLife, 4:uqad031
127. Fischer S, Van Tuan Trinh, Simon C, Weber LM, Forne I, Nist A, Bange G, Abendroth F, Stiewe T, Steinchen W, Liefke R, Vazquez O (2022). Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells. Cell Chemical Biology, 30(7):766-779.e11
126. Weiland P, Dempwolff F, Steinchen W, Freibert SA, Tian H, Glatter T, Martin R, Thomma BPHJ, Bange G*, Altegoer F* (2022). Structural and functional analysis of teh cerato-platinin effector protein Cpl1 suggests diverging functions in smut fungi. *co-corresponding authors
Molecular Plant Physiology, 24(7): 768-787
125. Zegarra-Leon V, Mais CM, Freitag J, Bange G (2023). The mysterious diadenosine tetraphosphate (AP4A). microLife, Volume 4, https://doi.org/10.1093/femsml/uqad016
124. Wątor E, Wilk P, Biela A, Rawski M, Zak K, Steinchen W, Bange G, Glatt S, Grudnik P (2023). Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nature Communications, 14(1):1698
123. Steubea N, Moldenhauer M, Weiland P, Samane D, Kilb A, Ramírez-Rojasa AA, Garga SG, Schindler D, Graumann PL, Benesche JLP, Bange G, Friedrich T, Hochberg GKA (2023). Fortuitously compatible protein surfaces primed allosteric control in cyanobacterial photoprotection.
Nature Ecology & Evolution, (5):756-767
122. Eugenio Leiva L, Zegarra V, Bange G*, Ibba M* (2023). At the crossroad of nucleotide dynamics and protein synthesis in bacteria. Microbiology and Molecular Biology Reviews (MMBR), 28:e0004422 *Equally contributing
121. Shearer HL, Van Loi V, Weiland P, Bange G, Altegoer F, Hampton MB, Antelmann H, Dickerhof N (2023). MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology, doi: 10.1111/mmi.15035
2022
120. Gratani F, Englert T, Nashier P, Sass P, Czech L, Neumann N, Doello Roman S, Mann P, Blobelt R, Alberti S, Forchhammer K, Bange G, Höfer K, Macek B (2022). E. coli toxin YjjJ (HipH) is a Ser/Thr protein kinase that impacts cell division, carbon metabolism and ribosome assembly. mSystems, 20:e0104322
119. Klemm P, Christ M, Altegoer F, Freitag J, Bange G*, Lechner M* (2022). Evolutionary reconstruction, nomenclature and functional meta-analysis of the Kiwellin protein family. Frontiers in Plant Sciences, 13:1034708
118. Herbel SM, Moyon L, Christ M, Elsayed EM, Malmsheimer S, Grin I, Surmann K, Blankenburg S, Jung AL, Caffrey BE, Herkt CE, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B (2022). Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones Virulence. Virulence 13(1):2042-2058
117. Corrales-Guerrero L, Steinchen W, Ramm B, Müksch J, Rosum J, Refes Y, Heimerl T, Bange G, Schwille P, Thanbichler M (2022). MipZ caps the plus-end of FtsZ polymers to trigger their rapid disassembly. PNAS, 119 (50) e2208227119
116. Shi YM, Crames JJ, Czech L, Bozhüyük KA, Shi YN, Hirschmann M, Lamberth S, Claus P, Paczia N, Rückert C, Kalinowski J, Bange G, Bode H (2022). Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria.
Angewandte Chemie Int Ed., 61(51):e202206106
115. Stoll J, Zegarra-Leon V, Bange G, Graumann PL (2022). Single-molecule dynamics suggest that ribosomes assemble at sites of translation in Bacillus subtilis. Frontiers in Microbiology, 13:999176.
114. Mühlenhoff U, Weiler BD, Nadler F, Millar R, Kothe I, Freibert SA, Altegoer F, Bange G, Lill R (2022). The ISC protein IBA57 executes a tetrahydrofolate-independent function in mitochrondrial 4Fe-4S protein maturation. Journal of Biological Chemistry, 298(10):102465.
113. Bange G, Wang JD (2022). A conserved alarmone as direct regulator of purine metabolism.
Nature Microbiology, 7, 1331-1332
112. Giammarinaro PI, Young MKM, Steinchen W, Mais CN, Hochberg G, Yang J, Stevenson DM, Amador-Noguez D, Paulus A, Wang JD, Bange G (2022). Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis. Nature Microbiology, 7(9):1442-1452.
111. Altegoer F, Quax TEF, Weiland P, Nußbaum P, Giammarinaro PI, Patro M, Li Z, Oesterhelt D, Grininger M, Albers SV, Bange G (2022). Structural insights into the mechanism of archaellar rotational switching. Nature Communications, 13(1):2857.
110. Schwartz PV, Nikolskiy I, Dannaoui E, Sommer F, Bange G, Schwartz P (2022). Synergistic in vitro action of isavuconazole and isoquercitrin against Candida glabrata. Journal of Fungi, 8(5):525.
109. Schwarz P, Nikolskiy I, Bidaud AL, Sommer F, Bange G, Dannaoui E (2022). In vitro synergy of isovuconaole combined with colistin against common Candida species. Frontiers Cellular and Infection MIcrobiology, 12:892893.
108. Rick T, Kreiling V, Höing A, Fiedler S, Glatter T, Steinchen W, Hochberg G, Bähre H, Seifert R, Bange G, Knauer SK, Graumann PL, Thormann KM (2022). A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by a direct interaction with a polar landmark protein. npj Biofilms and Microbiomes, 8(1):35.
107. Czech L, Mais CN, Kartzat H, Sarmah P, Giammarinaro P, Freibert S, Esser Esser H, Musial J, Berninghausen O, Steinchen W, Beckmann R, Koch HG, Bange G (2022). Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp. Nature Communications, 13(1):1069.
106. Zegarra V, Bedrunka P, Bange G, Czech L (2022). How to save a bacterial ribosome in times of stress. Seminars in Cell and Developmental Biology, 136:3-12.
105. Heinz V, Jäckel W, Kaltwasser S, Cutugno L, Bedrunka P, Graf A, Reder A, Michalik S, Dhople VM, Madej MG, Conway M, Lechner M, Riedel K, Bange G, Boyd A, Völker U, Lewis RJ, Marles-Wright J, Ziegler C, Pane-Farre J (2022). The Vibrio vulnificus stressosome: an oxygen-sensor involved in regulating iron metabolism. Communications Biology, 5(1):622.
104. Bremer E, Hoffmann T, Dempwolff F, Bedrunka P, Bange G (2022). The many faces of the unusual biofilm activator RemA. Bioessays, 15:e2200009.
103. Schwarz P, Nikolskiy I, Bidaurd AL, Sommer F, Bange G, Dannaoui E (2022). In vitro activity of amphotericin B in combination with colistin against fungi responsible for invasive infections. Journal of Fungi, 8(2):115.
2021
102. Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, Ruzic D, Hoffarth M, Xu J, Kaspareit J, Abendroth F, Royant A, Bange G, Nikolic K, Ryu S, Dou Y, Essen LO, Vazquez O (2021). Bistable photoswitch allows in vivo control of hematopoiesis. ACS Central Science, 8(1):57-66.
101. Osorio-Valeriano M, Altegoer F, Das CK, Steinchen W, Panis G, Connolley L, Giacomelli G, Feddersen H, Corrales-Guerrero L, Hanßmann J, Bramkamp M, Viollier PH, Murray S, Schäfer LV, Bange G, Thanbichler M (2021). The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes. Molecular Cell, 81/19):3992-4007.e10.
100. Hoffmann T, Mrusek D, Bedrunka P, Burchert F, Mais CN, Kearns DB, Altegoer F, Bremer E, Bange G (2021). Structural and functional characterization of the bacterial biofilm regulator RemA. Nature Communications, 12:5707.
99. Bange G, Brodersen DE, Liuzzi A, Steinchen W (2021). Two P or not P: Understanding regulation by the bacterial second messengers (p)ppGpp.
Annual Reviews in Microbiology, 75:383-406.
98. Kaspar F, Seeger M, Westarp S, Köllmann C, Lehmann A, Pausch P, Kemper S, Neubauer P, Bange G, Schallmey A, Werz DB, Kurreck A (2021). Diversification of 4'-methylated nucleosides by nucleoside phosphorylases.
ACS Catalysis, doi.org/10.1021/acscatal.1c02589
97. Feyh R, Wäber NB, Prinz S, Giammarinaro PI, Bange G, Hochberg G, Hartmann RK, Altegoer F (2021). Structure and mechanistic features of the prokaryotic minimal RNASeP. Elife, 10:e70160.
96. Pecina A, Schwan M, Blagotinsek V, Rick T, Klüber P, Leonhard T, Bange G, Thormann KM (2021). The stand-alone PilZ-domain protein MotL specifically regulates the activity of the secondary lateral flagellar system in Shewanella putrefaciens.
Frontiers in Microbiology, 12:668892
95. Mayer B, Schwan M, Oviedo-Bocanegra, Bange G, Thormann KM, Graumann P (2021). Dynamics of the signal recognition particle at a single molecule level. Frontiers in Microbiology, 12:663747
94. Potrykus K, Cashel M, Bange G (2021). (p)ppGpp and its Homologs: Enzymatic and Mechanistic Diversity among the microbes.
Frontiers in Microbiology, 12:658282
93. Troitsch A, Loi V, Zühlke D, Lalk M, Methling K, Riedel K, Bernhardt J, Elsayed E, Bange G, Antelmann H, Pane-Farre J (2021). Carbon source-dependent reprogramming of anaerobic metabolism in Staphylococcus areus.
Journal of Bacteriology, 203(8):e00639-20
92. Steinchen W, Ahmad S, Valentini M, Eilers K, Majkini M, Altegoer F, Lechner M, Filloux A, Whitney JC, Bange G (2021). Dual role of a (p)ppGpp- and (p)ppApp-degrading enzyme in biofilm formation and interbacterial antagonism.
Molecular Microbiology, 115(6):1339-1356
2020
91. Weng TH, Steinchen W, Beatrix B, Berninghausen O, Becker T, Bange G, Cheng J, Beckmann R (2020). Architecture of the active post-translational Sec translocon.
EMBO Journal, e10643. doi: 10.15252/embj.2020105643
90. Hook JC, Blagotinsek V, Pane-Farre J, Mrusek D, Altegoer F, Schier L, Thormann KM, Bange G (2020). A proline-rich element in the type III protein FlhB contributes to flagellar biogenesis in the beta- and gamma-proteobacteria.
Frontiers in Microbiology, doi: 10.3389/fmib.2020.564161
89. Pausch P, Abdelshahid M, Steinchen W, Schäfer H, Gratani FL, Freibert SA, Wolz C, Turgay K, Wilson DN, Bange G (2020). Structural basis for regulation of the opoosing (p)ppGpp synthetase and hydrolase within the stringent response regulator Rel.
Cell Reports, 32(11):108157
88. Blagotinsek V, Schwan M, Steinchen W, Mrusek D, John C. Hook, Rossman F, Freibert SA, Kratzat H, Murat G, Kressler D, Beckmann R, Beeby M, Thormann KM, Bange G (2020). An ATP-dependent partner switch mechanism links flagellar C-ring assembly with gene expression.
PNAS, 117(34):20826-20835
87. Bange G, Bedrunka P (2020). Physiology of the guanosine-based second messengers in Bacillus subtilis.
Biological Chemistry, doi: 10.1515/hsz-2020-0241
86. Lempp M, Lubrano P, Bange G, Link H (2020). Metabolism of non-growing bacteria.
Biological Chemistry, doi: 10.1515/hsz-2020-0201
85. Hermann L, Mais NC, Czech L, Smits S, Bange G*, Bremer E* (2020). The Ups and Downs of Ectoine. Structural enzymology of a major microbial stress protectant and versatile nutrient.
Biological Chemistry, doi: 10.1515/hsz-2020-0223 *Joint corresponding authors
84. Steinchen W, Zegarra V, Bange G (2020). (p)ppGpp: Magic modulators of bacterial physiology and metabolism.
Frontiers in Microbiology, in press
83. Wehrmann M, Elsayed EM, Köbbing S, Bendz L, Lepak A, Schwabe J, Wieckx, Bange G*, Klebensberger J* (2020)
An engineered PQQ-dependent alcohol dehydrogenase for the oxidation of 5-(hydroxymethyl)furoic acid.
ACS Catalysis doi:10.1021/acscatal.0c01789 *Joint corresponding authors
82. Krol E, Yau H, Lechner M, Schäper M, Bange G, Vollmer W, Becker A (2020). Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti.
MBio, 11(3):e00306-20
81. Mais CN, Hermann L, Altegoer F, Seubert A, Richter AA, Wernersbach I, Czech L, Bremer E, Bange G (2020). Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex.
Journal of Biological Chemistry, 295(27):9087-9104
80. Altegoer F, Weiland P, Giammarinaro PI, Freibert SA, Binnebesel L, Han X, Lepak A, Kahmann R, Lechner M, Bange G (2020). The two paralogous kiwellin proteins KWL1 and KWL1-b from maize are structurally related and have overlapping functions in plant defense.
Journal of Biological Chemistry, 295(23):7816-7825
79. Mazzantini D, Fonnesu R, Celandroni F, Calvigioni M, Vecchione A, Mrusek D, Bange G, Ghelardi E (2020). GTP-dependent FlhF homodimer supports secretion of a hemolysin in Bacillus cereus.
Frontiers in Microbiology, 11:879
78. Skotnicka D, Steinchen W, Szadkowski D, Cadby I, Lovering A, Bange G, Sogaard-Andersen L (2020). CdbA is a DNA-binding protein and c-di-GMP receptor important for nucleoid organization and segregation in Myxococcus xanthus.
Nature Communications, 11(1):1791
77. Corrales-Guerrero L, He B, Refes Y, Panis G, Bange G, Viollier PH, Steinchen W, Thanbichler M (2020). Molecular architecture of the DNA-binding sites of the P-loop ATPases MipZ and ParA from Caulobacter crescentus.
Nucleic Acids Research, 48(9):4769-4779
76. Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss A, Beckstette M, Hantke I, Driller K, Sudzinova P, Krasny L, Kaever V, Dersch P, Bange G*, Wilson DN*, Turgay K* (2020). The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
PLOS Genetics, 16(3):e1008275 *Joint corresponding authors
75. Petersen I, Schlüter I, Hoff KJ, Liebscher V, Bange G, Riedel K, Pane-Farre J (2020).
Non-invasive and label-free 3D visualization shows in vivo oligomerization of the staphylococcal alkaline shock protein 23 (Asp23).
Scientific Reports, 10(1):125
2019 and before
74. Osorio-Valeriano M, Altegoer F, Steinchen W, Urban S, Liu Y, Bange G*, Thanbichler M* (2019).
ParB-type DNA seggregation proteins are CTP-dependent molecular switches.
Cell, 179(7):1512-1524.e15 * Joint corresponding authors
73. Richter A, Mais CN, Czech L, Geyer K, Hoeppner A, Smits SHJ, Erb TJ, Bange G, Bremer E (2019).
Biosynthesis of the stress-protectant ectoine: biochemistry of the transaminase EctB.
Frontiers in Microbiology, DOI: 10/3389/fmicb.2019.02811
72. Najafi J, Altegoer F, Bange G, Wagner C (2019).
Swimming of bacterium Bacillus subtilis with multiple bundles of flagella.
Soft Matter 15(48)10029-10034
71. Michel C, Mack EKM, Mais CN, Fritz LV, Wang Y, Jehn LB, Hühn SK, Simon C, Inselmann S, Marquardt A, Kremer J, Wollmer E, Sohlbach K, Neubauer A, Brendel CA, Haferlach C, Bange G, Burchert A (2019).
Cloning and characterization of a novel druggable fusion kinase in acute myeloid leukemia.
Haematologica, doi: 10.3324/haematol.2019.237818
70. Altegoer F and Bange G (2019).
Plants strike back: Kiwellin proteins as modular toolbox for plant defense mechanisms.
Communicative&Integrative Biology https://doi.org/10.1080/19420889.2019.1586049
69. Han X, Altegoer F, Steinchen W, Binnebesel L, Schuhmacher J, Glatter T, Giammarinaro PI, Djamei A, Rensing SA, Reissmann S, Kahmann R and Bange G (2019).
A kiwellin disarms the metabolic activity of a secreted fungal virulence factor.
Nature 565(7741):650-653
68. Rossmann FM, Rick T, Mrusek D, Sprankel L, Leomhard T, Dörrich AK, Bubendorfer S, Kaever V, Bange G, Thormann K (2019).
The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP.
Journal of Bacteriology, DOI: 10.1128/JB.00534-18
67. Kushwaha GS, Bange G, Bhavesh NS (2019).
Interaction studies on bacterial stringent response protein RelA with uncharged tRNA provide evidence for its prerequisite complex for ribosome binding.
Current Genetics, doi: 10.1007/s00294-019-00966-y
66. Özcan A, Pausch P, Linden A, Wulf A, Schühle K, Heider J, Urlaub H, Heimerl T, Bange G, Randau L (2019).
Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum.
Nature Microbiology, 4(1):89-96
65. Pausch P, Steinchen W, Wieland M, Klaus T, Freibert SA, Altegoer F, Wilson DN, Bange G (2018).
Structural basis for the (p)ppGpp-mediated inhibition of the GTPase RbgA.
Journal of Biological Chemistry, doi: 10.1074/jbc.RA118.003070
64. Bernhardsgrütter I, Vögeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobe F, Maury O, Shima S, Zarzycki, Erb TJ (2018). The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite.
Nature Chemical Biology, https://doi.org/10.1038/s41589-018-0153-x
63. Richter A, Hölscher T, Pausch P, Sehrt T, Brockhaus F, Bange G, Kovacs AT (2018).
Hampered motility promotes the evolution of wrinkly phenotype in Bacillus subtilis.
BMC Evolutionary Biology, 16; 18(1):155
62. Dragos A, Martin M, Garcia CF, Kricks L, Pausch P, Heimerl T, Balint B, Maroti G, Bange G, Lopez D, Lieleg O Kovacs AT (2018).
Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms.
Nature Microbiology, https://doi.org/10.1038/s41564-018-0263-y
61. Najafi J, Shaebani MR, John T, Altegoer, F, Bange G, Wagner C (2018).
Flagellar number governs bacterial spreading and transport efficiency.
Science Advances, 4: eaar6425
60. Gleditsch D, Pausch P, Müller-Esparza H, Özcan A, Guo X, Bange G, Randau L (2018).
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures.
RNA Biology, DOI: 10.1080/15476286.2018.1504546
59. Altegoer A, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G (2018).
FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.
Scientific Reports 8:11552
58. Brenzinger S, Pecina A, Mrusek D, Mann P, Völse K, Wimmi S, Ruppert U, Becker A, Ringgaard S, Bange G, Thormann KM (2018). ZomB is essential for flagellar motor reversals in Shewanella putrefaciens and Vibrio parahaemolyticus.
Molecular Microbiology doi: 10.1111/mmi.14070.
57. Gratani FL, Horvatek P, Geiger T, Borisova M, Mayer C, Grin I, Wagner S, Steinchen W, Bange G, Velic A, Maček B, Wolz C (2018). Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus.
PLoS Genetics 14, (7):e1007514
56. Ma LS, Wang L, Trippel C, Mendoza-Mendoza A, Ullmann S, Moretti M, Carsten A, Kahnt J, Reissmann S, Zechmann B, Bange G, Kahmann R (2018). The Ustilago maydis effector Rsp3 blocks the antifungal activity of mannose-binding maize proteins.
Nature Communications, doi: 10.1038/s41467-018-04149-0
55. Karniel A, Mrusek D, Steinchen W, Dym O, Bange G, Bibi E (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle (SRP)- receptor.
Journal of Molecular Biology, https://doi.org/10.1016/j.jmb.2018.04.017
54. Steinchen W, Vogt MS, Altegoer F, Giammarinaro PI, Horvatek H, Wolz C, Bange G (2018). Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ.
Scientific Reports DOI:10.1038/s41598-018-20634-4
53. Quax TEF, Altegoer F, Rossi F, Li Z, Rodriguez-Franco M, Kraus F, Bange G*, Albers SV* (2018).
Structure and function of the archaeal response regulator CheY.
PNAS, doi:10.1073/pnas.1716661115; * Joint corresponding authors
52. Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R (2017). Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Cell 171, 1599–1610
51. Steinchen W, Linne U, Bange G (2017). HDX-MS in den modernen Lebenswissenschaften.
Biospektrum, DOI: 10.1007/s12268-017-0871-8
50. Pausch P, Müller-Esparza H, Gleditzsch D, Altegoer F, Randau L, Bange G (2017). Structural variation of type I-F CRISPR RNA guided DNA surveillance.
Molecular Cell, 67(4):622-632
49. Schäper S, Steinchen W, Krol E, Altegoer F, Skotnicka D, Søgaard-Andersen L, Bange G*, Becker A* (2017).
AraC-like transcriptional activator CuxR binds c-di-GMP by a PilZ-like mechanism to regulate extracellular polysaccharide production.
PNAS 114(24):E4822-E4831; *Joint corresponding authors
48. Weyer FA, Gumiero A, Lapouge K, Bange G, Kopp J, Sinning I (2017).
Structural basis of HypK regulating N-terminal acetylation by the NatA complex.
Nature Communications 6;8:15726. doi: 10.1038/ncomms15726.
47. Gessner C, Steinchen W, Bedard S, Skinner JJ, Woods VL, Walsh TJ, Bange G, Pantazatos D (2017).
Computational method allowing hydrogen-deuterium exchange mass spectrometry at single amide resolution.
Scientific Reports, doi:10.1038/s41598-017-03922-3
46. Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G*, Turgay K*, Wilson DN* (2017).
Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.
EMBO Journal doi: 10.15252/embj.201696189; *Joint corresponding authors.
45. Li A, Wang B, Ilie A, Dubey KD, Bange G, Korendovych I, Shaik S, Reetz MT (2017).
A redox-mediated Kemp eliminase.
Nature Communications doi:10.1038/ncomms14876
44. Bange G & Waldminghaus T (2016).
Editorial Overview: Synthetic Biology - From understanding to engineering biology and back.
Current Opinion in Chemical Biology 34:151-153
43. Altegoer FA, Rensing S, Bange G (2016).
Structural basis for the CsrA-dependent modulation of translation initiation by an ancient regulatory protein.
PNAS 113(36):10168-73
42. Fage CD, Hegemann JD, Nebel AJ, Steinbach R, Zhu S, Linne U, Harms K, Bange G, Marahiel MA (2016).
Structure and mechanism of the Shingopyin I Lasso Peptide Isopeptidase
Angewandte Chemie International Edition 55(41):12717-21
41. Blauenburg B, Mielcarek A, Altegoer A, Fage CD, Linne U, Bange G, Marahiel MA (2016). Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.
PLOS One 11(7):e0158749
40. Steinchen W & Bange G (2016).
The magic dance of the alarmones (p)ppGpp.
Molecular Microbiology 101(4):531-44
39. Wild K*, Bange G*, Motiejunas D, Kribelbauer J, Hendricks A, Segnitz B, Wade RC, Sinning I (2016).
Structural basis for conserved regulation and adaptation of the signal recognition particle targeting complex.
Journal of Molecular Biology 428(14):2880-97; *Equally contributing authors
38. Gleditzsch D, Müller-Esparza H, Pausch P, Sharma K, Dwarakanath S, Urlaub H, Bange G, Randau L (2016). Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system.
Nucleic Acids Research 44(12):5872-82
37. Steinchen W, Schuhmacher J, Altegoer F, Fage C, Srinivasan V, Linne U, Marahiel M, Bange G (2015).
Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
PNAS 112(43):13348-53
36. Altegoer F & Bange G (2015).
Undiscovered regions on the molecular landscape of flagellar assembly.
Current Opinion in Microbiology 28:98-105
35. El-Andari J, Altegoer F, Bange G, Graumann PL (2015).
Bactofilins are essential for flagellar hook- and filament assembly and dynamically localize into structures of less
than 100 nm diameter underneath the cell membrane.
PLOS One 10(10):e0141546
34. Schuhmacher J, Thormann KM and Bange G (2015).
How bacteria maintain location and number of flagella.
FEMS Reviews Microbiology 39(6):812-22
33. Schuhmacher JS, Rossmann F, Dempwolff F, Knauer C, Altegoer F, Steinchen W, Dörrich A, Klingl A, Stephan M, Linne U, Thormann K and Bange G (2015). The MinD-like ATPase FlhG effects location and number of bacterial flagella during C-ring assembly.
PNAS 112 (10), 3092-7
32. Rossmann F, Brenzinger S, Knauer C, Bubendorfer, S, Ruppert U, Bange G, Thormann K (2015).
The role of FlhF and HubP as polar landmark proteins in Shewanella putrefaciens CN-32.
Molecular Microbiology 98(4):727-42
31. Gulbronson CJ, Ribardo DB, Balaban B, Knauer C, Bange G, Hendrixson DR (2015).
FlhG Employs Diverse Intrinsic Domains and Influences FlhF GTPase Activity to Numerically Regulate Polar Flagellar Biogenesis in Campylobacter jejuni.
Molecular Microbiology 99(2):291-306
30. Pausch P, Singh U, Ahmed YL, Pillet B, Murat G, Altegoer F, Stier G, Thoms M, Hurt E, Sinning, I, Bange, G*, Kressler D* (2015).
Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nature Communications 26;6:7494, *Joint corresponding authors
29. Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, and Grosse R (2015).
Formin-like 2 Promotes β1-integrin Trafficking and Invasive Motility Downstream of PKCa.
Developmental Cell 34(4):475-83
28. Calvino F , Kharde S, Ori A, Hendricks A, Wild K, Kressler D, Bange G, Hurt E, Beck M, Sinning I (2015).
Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA binding site.
Nature Communications (6):6510
27. Pillet B, García-Gómez JJ, Pausch P, Falquet F, Bange G, de la Cruz J, Kressler D (2015).
The dedicated chaperone Acl4 escorts ribosomal protein Rpl4 to its nucelar pre-60S assembly site.
PLOS Genetics 11(10):e1005565
26. Giessen T, Altegoer F, Nebel AJ, Steinbach RM, Bange G*, Marahiel M* (2015).
A synthetic adenylation domain-based tRNA-aminoacylation catalyst.
Angewandte Chemie International Edition 54 (8), 2492 - 6, *Joint corresponding authors
25. Altegoer F, Schuhmacher J, Pausch P, Bange G (2014).
From molecular evolution to biobricks and synthetic modules: A lesson by the bacterial flagellum.
Biotechnology and Genetic Engineering Reviews 30: 49-64
24. Leidig C, Thoms M, Holdermann I, Bradatsch B, Berninghausen O, Bange G, Sinning I, Hurt E, Beckmann R. (2014).
60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nature Communications 5: 3491
23. Bange G* & Sinning I* (2013).
SIMIBI Twins in protein targeting and localization.
Nature Structural & Molecular Biology 20, 776 - 780 *Joint corresponding authors
22. Bange G*, Murat G, Sinning I, Hurt E, Kressler D*. (2013).
New twist to nuclear transport: When two travel together.
Communicative and Integrative Biology 6:4, e24792 *Joint corresponding authors
21. van Noort V, Bradatsch B, Arumugam M, Amlacher S, Bange G, Creevey C, Falk S, Mende DR, Sinning I, Hurt E, Bork P (2013).
Consistent mutational paths predict eukaryotic thermostability.
BMC Evolutionary Biology 13(1):7
20. Leidig, C*, Bange G*, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I (2013).
Structural characterization of a eukaryotic co-translational chaperone, the ribosome-associated complex (RAC).
Nature Structural & Molecular Biology 20(1):23-28 *Equally contributing
19. Kressler D*, Bange G*, Ogawa Y, Stjepanovic G, Bradatsch B, Pratte D, Amlacher S, Strauß D, Yoneda Y, Katahira J, Sinning I, Hurt E (2012).
Synchronizing nuclear import of ribosomal proteins for ribosome assembly.
Science 338(6107): 666-71 *Equally contributing
18. Bange G*, Kümmerer N, Grudnik P, Lindner R, Petzold G, Kressler D, Hurt E, Wild K, Sinning I* (2011).
Structural basis for the molecular evolution of SRP-GTPase activation by protein.
Nature Structural & Molecular Biology 18(12):1376-80 *Joint corresponding authors
17. Stjepanovic G, Kapp K, Bange G, Graf C, Parlitz R, Wild K, Mayer MP, Sinning I (2011).
Lipids trigger a conformational switch regulating SRP-mediated protein targeting.
Journal of Biological Chemistry 286(26):23489-97
16. Sinning I, Bange G, Wild K (2011).
It takes two to Get3.
Structure 19(10):1353-5.
15. Bange G, Kummerer N, Engel C, Bozkurt G, Wild K and Sinning I (2010).
FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system.
PNAS 107, 11295-11300.
14. Wild K, Bange G, Bozkurt G, Segnitz B, Hendricks A, Sinning I (2010).
Structural insights into the assembly of the human and archaeal signal recognition particles.
Acta Crystallogr D Biol Crystallogr 66, 295-303.
13. Sinning I, Wild K, Bange G (2009)
Signal sequences get active.
Nature Chemical Biology 5, 146-147.
12. Bozkurt G, Stjepanovic G, Vilardi F, Amlacher S, Wild K, Bange G, Favaloro V, Rippe K, Hurt E, Dobberstein B, Sinning I (2009).
Structural insights into tail-anchored protein binding and membrane insertion by Get3.
PNAS 106, 21131-21136.
11. Grudnik P, Bange G, Sinning I (2009).
Protein targeting by the signal recognition particle.
Biological Chemistry 390, 775-782.
10. Bange G, Petzold G, Wild K, Parlitz RO, Sinning I (2007).
The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP.
PNAS 104, 13621-13625.
9. Bange G, Petzold G, Wild K, Sinning I (2007).
Expression, purification and preliminary crystallographic characterization of FlhF from Bacillus subtilis.
Acta CrystallogrSect F Struct Biol Cryst Commun 63, 449-451
8. Bange G, Wild K, Sinning I (2007).
Protein translocation: checkpoint role for SRP GTPase activation.
Current Biology 17, R980-982
7. Bradatsch B, Katahira J, Kowalinski E, Bange G, Yao W, Sekimoto T, Baumgartel V, Boese G, Bassler J, Wild K, et al. (2007).
Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit.
Molecular Cell 27, 767-779
6. Kowalinski E, Bange G, Wild K, Sinning I (2007).
Expression, purification, crystallization and preliminary crystallographic analysis of the proliferation-associated protein Ebp1.
Acta Crystallogr Sect F Struct Biol Cryst Commun 63, 768-770.
5. Parlitz R, Eitan A, Stjepanovic G, Bahari L, Bange G, Bibi E, Sinning I (2007).
Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix.
Journal of Biological Chemistry 282, 32176-32184.
4. Bange G*, Kowalinski E*, Bradatsch B, Hurt E, Wild K, Sinning I (2007).
The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
FEBS Letters 581, 4450-4454 *Equally contributing authors
3. Peplowska K, Markgraf DF, Ostrowicz CW, Bange G, Ungermann C (2007).
The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.
Developmental Cell 12, 739-750.
2. Gupta A, Breese K, Bange G, Neubauer P (2004).
Enzymatic method for the enantioselective reduction of keto compounds.
United States Patent Number 20040265978.
1. Gupta A, Breese K, Bange G, Neubauer P (2001).
Enzymatisches Verfahren zur Reduktion von Ketoverbindungen.
Patent no. DE 101 19 274.6, EP0204143, (AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR)
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