Current Research Questions

At BangeLab, we explore how cells sense and respond to stress through small but powerful molecular signals - nucleotides. Our research focuses on “alarmone” molecules such as (p)ppGpp and Ap4A, which rapidly reprogram cellular processes in response to environmental and metabolic challenges. By uncovering how these nucleotide signals control growth, survival, and adaptation, we aim to reveal fundamental principles of cellular regulation and identify new avenues for therapeutic intervention.

Cells constantly adjust their metabolism to thrive in chaging enviorments, balancing energy production, growth, and survival. At BangeLab, we investigate how key metabolites, suchas acetyl-CoA energy production, growth, and survival. At BangeLab, we investigate how key metabolites such as acetyl-CoA, NAD, NADP, and FAD act not only as metabolic intermediates but also as signals that shape cellular behavior—for example through protein acetylation and redox-dependent regulation. By uncovering how these molecular cues coordinate metabolic pathways and regulatory networks, we reveal fundamental principles of cellular decision-making and adaptation.

Macromolecular machines are the engines of life - complex assemblies of proteins and nucleic acids that build, move, and regulate the cell with high precision. At BangeLab, we study how these systems are assembled and controlled in time, space, and number.

The ribosome and the flagellum exemplify this: the ribosome translates genetic information into proteins with remarkable accuracy, while the flagellum is a rotary motor that propels cells and is assembled stepwise across the cell envelope. Despite their differences, both rely on tightly coordinated assembly and regulation to ensure they form at the right place, time, and quantity.

Cells rely on distinct organelles to organize biochemical processes in space and ensure efficient, regulated function. Establishing organelle identity ensures that each compartment contains the right proteins, lipids, and activities at the right time. Peroxisomes exemplify this principle through selective protein import, membrane composition, and dynamic turnover, supporting key roles in lipid metabolism and redox balance. Similarly, mitochondria and chloroplasts serve as specialized metabolic hubs for energy conversion and biosynthesis. Importantly, organelle identities are not isolated: contact sites between compartments enable the exchange of metabolites, proteins, and signals, allowing cells to coordinate functions and adapt metabolism to changing conditions